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Several strains of bacteria in the soil can make a meal of the world's most potent antibiotics, researchers said, in a startling finding that illustrates the extent to which these germ-fighting drugs are losing the war against (1) superbugs.
A study of soil microbes taken from 11 sites uncovered bacteria that could withstand antibiotics 50 times stronger than the standard for bacterial resistance.
"It certainly was very surprising to us," said George Church, a geneticist at Harvard Medical School in Boston, whose research appears in the journal Science.
"Many bacteria in many different soil isolates can not only tolerate antibiotics, they can actually live on them as their sole source of nutrition," Church said.
Other researchers have found antibiotic-eating strains of bacteria, but Church's study is among the most systematic. It offers more clues about why bacteria quickly develop resistance to antibiotics, and why drug companies must constantly develop new antibiotics to defeat them.
Church's team initially set out to find organisms in the soil that remove toxins from cellulose. They took samples from a variety of sites, including a cornfield fertilized by manure from cows that were fed antibiotics.
Microbes taken from these soil samples could easily defeat toxins from cellulose, which they expected. Then the researchers tested the microbes against antibiotics, something they thought would be toxic.
Surprised by how easily the microbes devoured the antibiotics, Church and colleagues did a broader test, exposing hundreds of microbes to 18 antibiotics representing most of the major classes of naturally occurring and synthetic antibiotics,including penicillin and the widely prescribed antibiotic ciprofloxacin. ■Reuters
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