»´ä¤å¶×³ø°T¡]°OªÌ ð¹Åº½¡^»´ä¤H¤f«ùÄò¦Ñ¤Æ¡A·í¤¤¦Ñ¦~¤H¤f¬ù¦³5%¦Ü8%¦]¸£¯«¸g°h¤Æ¦Ó±w¦³»{ª¾»Ùê¯g¡A±©²{®ÉÂå¾Ç¬É¤´¥¼¦³®Úªv¯«¸g·l¶Ëªº¤èªk¡A·í¤¤¥Dn»Ùê¬O¦p¦ó«·s³s±µ±wªÌ¤j¸£¤¤¨ü·lªº¯«¸g¤¸¡C¤¤¤å¤j¾Ç¬ã¨s¹Î¶¤µo²{¤F¤@ºØ¨ë¿E¯«¸g¬ð¡]neurite¡^¥Íªøªº·s¾÷¨î¡A¥i¨ë¿E¯«¸g¬ð¦A¥Í¡A¬°§Q¥Î¦A¥ÍÂå¾Ç¤èªk«·s³s±µ¸£¯«¸g´£¨Ñ¤F«n±Ò¥Ü¡C
¹Î¶¤«ü¡A·sµo²{¦³±æÀ°§U×´_¥Ñ³Ð¶Ë©Ê¸£·l¶Ë¡]TBI¡^³y¦¨ªº¯«¸g·l¶Ë¡A©MÀ³¹ï¯«¸g°h¤Æ©Ê¯e¯f¡A§Æ±æ¥¼¨Ó¥i¬ãµo¥X¬ÛÃöªvÀøÃĪ«¡C
¤j¸£¬O°Êª«ªº«ü´§¤¤¤ß¡A¥Ñ¯«¸g¤¸²Õ¦¨¡C¯«¸g¤¸³z¹L±q²ÓMÅ餺ªø¥Xªº¯«¸g¬ð»P¨ä¥L¯«¸g¤¸³s±µ§Î¦¨¯«¸gºôµ¸¡A¤¬¬Û³q«H¡A¥H½Õ±±¤£¦Pªº»{ª¾¥\¯à©M¨Å鬡°Ê¡C
Y¯«¸g¬ð¥X²{°h¤Æ©M¦^ÁY¡A«hµLªkºû«ù¯«¸gºôµ¸ªº¥¿±`Ápô®É¡A±wªÌªº»{ª¾»Ùê©M¨Å骺¹B°Ê¥\¯à±NÃø¥H«ì´_¡C
¤¤¤j¥Í©R¬ì¾Ç¾Ç°|°Æ±Ð±Â¼B°ê½÷¤Î¨ä¬ã¨s¹Î¶¤¦Û2014¦~°_®i¶}¬ã¨s¡A¦¨¥\µo²{¤F¤@ºØ¨ë¿E¯«¸g¬ð¥Íªøªº·s¾÷¨î¡C
¸£³J¥Õ¬Û¤¬§@¥Î ¨ë¿E¯«¸g¬ð¥Íªø
¹Î¶¤º¥ýµo²{¡A¤j¸£¤¤ªº°ªªí¹FÂà±µ³J¥Õ¡uFE65¡v»P¨ë¿E¯«¸g¬ð¥Íªø¦³Ãö¡A¨ä«á¦b2¸U¦hÓ¤HÅé°ò¦]¤¤¡A§ä¥X16Ó»P¡uFE65¡vµo¥Í¬Û¤¬§@¥Îªº³J¥Õ¡Aµo²{¡uFE65¡v»P¼sªxªí¹Fªº³J¥Õ¡uELMO1¡v¤§¶¡¬Û¤¬§@¥Î¡A¥i¨ë¿E¯«¸g¬ð¥Íªø¡C
¬ã¨s¹Î¶¤§Q¥Î¦Ñ¹«¶i¦æ¹êÅç¡A¤À§O¦³¥[¤J¡uFE65¡v©M¡uELMO1¡vªº¹êÅç²Õ§O¡A¤Î¤@¯ë¹ï·Ó²Õ§Oµ¥¡C¹Î¶¤Æ[¹î¯«¸g¬ð¤¤¶b¬ðªø«×¡Aµ²ªGµo²{¦P®É¥[¤J¨âºØ³J¥Õªº²Õ§O¡A¶b¬ð¦b¨â¤Ñ¤º¥iªø¦Ü¥§¡120²@¦Ì¡A¸û¹ï·Ó²Õ§Oªº40²@¦Ì¡A¼W¥[¤F¨â¿¡C
¼B°ê½÷ªí¥Ü¡A¡u³q¹L½Õ±±¡yFE65-ELMO1¡z¬Û¤¬§@¥Î¡A¥i¥H¨ë¿E³o¨Ç²ÓM¤¤ªº¯«¸g¬ð¦A¥Í¡A±q¦Ó¹ê²{¨ü·l¯«¸g¤¸ªº«·s³s±µ¡C¡v
¬ã¨s¹Î¶¤ÁÙ¶i¤@¨Bµo²{¡A³oºØ¬Û¤¬§@¥ÎÅX¨Ï¡uELMO1¡v²¾¦V²ÓM½è½¤¡A±q¦Ó¿E¬¡½¤¤Wªº¡uRac1¡v³J¥Õ¡C¯«¸g¬ð©µ¦ù¥²¶·¸g¹L²ÓM°©¬[«¶ì¹Lµ{¡A¦Ó¡uRac1¡v ¬O³oÓ¹Lµ{ªºÃöÁä½Õ¸`¦]¤l¡A¬°§Q¥Î¦A¥ÍÂå¾Ç¤èªkªvÀø¸£·l¶Ë´£¨Ñ¤F·sªº¤è¦V¡C¥¼¨Ó¹Î¶¤§Æ±æ¥i§ó¤F¸Ñ·s¾÷¨îªºI«áì²z¡A¦³±æ¤é«á¬ãµo¥XÃĪ«¡A«·s±N¨ü·lªº¯«¸g¤¸³s±µ¡C
¬ã¨s¦¨ªG¤w©ó¬ü°ê¥Íª«¤Æ¾Ç»P¤À¤l¥Íª«¾Ç¾Ç·|ªºµÛ¦W´Á¥Z¡mJournal of Biological Chemistry¡n5¤ë¸¹¤W¥Zµn¡C